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Alert Number 66

An Early Christmas Present from Blood

Date: December 20, 2004

Two articles that are of great interest to CLL patients will be published in Blood on January 1, 2005. Blood is the top rated journal for hematology. It has high standards for peer-reviewed articles. This is an early Christmas present for us - full text versions of both are available free of charge, just by clicking on the links given below.

Dr. Montserrat's editorial comments on the Byrd et. al. paper is aptly named "CLL therapy: progress at last!". I second that sentiment, especially in the context of the work coming out of CALGB, under the leadership of some of our best CLL researchers.

Blood, January 1, 2005

Blood Journal Editorial

CLL therapy: progress at last!

Emili Montserrat

University of Barcelona

Blood Journal Article (Free full-text)

The Addition of Rituximab to Fludarabine May Prolong Progression-Free Survival and Overall Survival in Patients with Previously Untreated Chronic Lymphocytic Leukemia: An Updated Retrospective Comparative Analysis of CALGB 9712 and CALGB 9011.

Byrd JC, Rai K, Peterson BL, Appelbaum FR, Morrison VA, Kolitz JE, Shepherd L, Hines JD, Schiffer CA, Larson RA.

We have already reviewed on our website this retrospective comparison between fludarabine monotherapy versus the combination of fludarabine + Rituxan that Byrd, et al., report in their paper. While this seminal paper is just being published on Blood as a hard copy version, we got hold of it months ago, prepublished online as a Blood First Edition Paper on May 11, 2004 and reviewed it on May 13, 2004. CLL Topics gets you the latest stuff, often before it is available in the hard copy print version! If you wish to read our review and comments of the F vs RF comparison, please click on the link given below. You may also be interested in reading a more recent article in which we discussed the information presented by Dr. Byrd, et. al., at the latest ASH meeting. It gives you a perspective on the length of the remissions and how they may differ between patients in different risk "buckets".

Fludarabine Monotherapy No Longer the Gold Standard
Shopping for the Therapy that is Right for You

Be well, happy reading!


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