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Alert Number 256

Grim News for Refractory Patients

Date: October 14, 2007

All too often, the emphasis of research and clinical trials is focused on newly diagnosed or “naïve” ( = previously untreated) patients. But the grim reality is that except for a minority of exceptionally lucky CLL patients with truly smoldering disease that never needs treatment, for most of us the disease will progress over time and will need therapy to control it.

The latest article on our website, Refractory CLL, is all about the choices and risks faced by patients who are fludarabine refractory (and potentially some of these guys are Campath ineligible as well). If you are the type that would rather know what you are facing straight up, read on. Frankly, I do not see how else one can make smart therapy choices. But if you are feeling a tad vulnerable right now, it is not a bad idea to bookmark this article for reading at a later time. But do read it at some point – I would not want you to walk into this minefield with eyes tight shut.

Be well,


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