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Alert Number 174

David vs. Goliath - Comparing HuMax-CD20 with Rituxan

Date: July 20, 2006

What makes the new-kid-on-the-block HuMax-CD20 different from the present favorite Rituxan?

I have been pondering this question as I have watched my old friend “Harvey” responding better than I could have hoped to his latest round of therapy with HuMax-CD20, after developing serious hypersensitivity reactions to Rituxan. Compared to Rituxan, HuMax-CD20 is a new upstart. Will this David have any success in taking on the established Goliath of Rituxan? In our latest article A Smarter Monoclonal on Trial I review some of the differences between the two drugs, what makes them tick, why they seem to behave so differently in CLL patients.

We also discuss the full details of the just announced multi-center, Phase-3 clinical trial of Humax-CD20. This trial will recruit 100 CLL patients across the USA and Europe, patients who have relapsed after using fludarabine and Campath. A word to the wise: I think this trial is going to be over-subscribed pretty quickly, so if you are interested you should check it out right away. Not all the centers are recruiting yet, but they should start doing so in the next little while. If you are interested in this trial, you should get your ducks in a row and perhaps have your name on their list of patients looking to enroll.

Be well,


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