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Alert Number 164

Harvey is Back! An Update on Genmab's HuMax-CD20

Date: May 26, 2006

Our hypothetical patient “Harvey” is back from the U.K., where he underwent “compassionate use” therapy with the new fully humanized monoclonal antibody HuMax-CD20. You can see how our intrepid hero fared with the new therapy in our new article Genmab in the News.

Genmab’s HuMax-CD20 is going to be an important drug for CLL patients. It has been fast-tracked for that application by the FDA, and someday soon it may really give Rituxan a run for its money. The fact that it is a fully humanized monoclonal may give it advantages over the chimeric (half-mouse, half-human protein) Rituxan, in terms of allergic reactions and the like. Genmab has just announced a large Phase-3 clinical trial of their drug, and we have reviewed their trial protocol as well in this article. You can bet we will be following this new trial closely, and keeping touch with the company behind the drug. Keep an eye out for additional information in the near future.

Be well,


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