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Alert Number 150

Rituxan Adverse Effects

Date: February 9, 2006

Since our hypothetical patient Harvey has developed a modest following of his own, I thought I had best report on new developments. Harvey's latest experience coincides with recently published reports on new adverse effects of Rituxan therapy.

While the post-marketing surveillance of Rituxan has so far identified only a small percent of patients having these problem, the danger is high and very real for these patients, and therefore worth discussing. Please make sure you read this latest article on our website if you have had Rituxan therapy recently, especially if you have experienced skin and mucosal problems, or GI tract / pulmonary problems a few days to a couple of months after end of therapy. These adverse effects are in addition to previously identified warnings about delayed onset neutropenia and possible viral reactivation of hepatitis. In patients where these newly identified symptoms of drug hypersensitivity is confirmed, Rituxan may be contra-indicated in the future.

Rituxan Road-block

Happy Valentine's Day! I wish I had better news to share with you today.

Be well,


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