CLL Topics Banner: Therapies, Research and Patient Education for Chronic Lymphocytic Leukemia
CLL Topics Home Navigation Topics Alert Learning Tools About Us Feedback Feedback
Full Menu

Topics Alert

world balloon

Topics Alert Archive

Alert Number 134

Three New CLL Clinical Trials - All Targeting Bcl-2

Date: November 2, 2005

Eternal life is not a good thing, not when we are talking about CLL cells.

One of the major reasons why CLL cells accumulate inexorably in your body is that they do not die on command, as they are supposed to. Healthy cells are well behaved, obediently committing suicide when commanded to do so. This process of culling out over-the-hill or defective cells is called apoptosis, and it is a very important process in our bodies. Bcl-2 is a family of proteins that controls apoptosis. In many cancer cells including CLL, there is too much of the anti-death Bcl-2 protein, protecting the malignant cells from dying. The anti-apoptosis Bcl-2 protein also makes CLL cells resistant to chemotherapy.

We have just published a brand new article (Targeting Bcl-2) reviewing three different clinical trials presently underway testing agents that target Bcl-2, as a way of “encouraging” the CLL cells to die a dignified death. One of these agents, Genasense, has been around for a few years. The other two are small molecule drugs that are being tested at Georgetown University and UCSD. If you are considering volunteering for one of these trials, you would be well advised to read our review. We also have comments from Genta’s CEO after reviewing our Genasense article.

Be well,


NOTICE: This page from the Topics Alert archive was originally emailed to subscribers of Topics Alert, a free service of CLL Topics Inc. If you are not a subscriber and you wish to receive email Alerts, please register at the Topics Alert subscription page. The content of this page is intended for information only and it is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.

Go to Alert Archive Listing

You may also retrieve a different Alert,
by entering a new Alert number here
(in the range 1 to 309)



Disclaimer: The content of this website is intended for information only and is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.

Copyright Notice:

Copyright © 2002-2007 CLL Topics, Inc. All Rights Reserved.

All materials contained on this site are protected by United States copyright law and may not be reproduced, distributed, transmitted, displayed, published or broadcast without the prior written permission of CLL Topics, Inc. You may not alter or remove any trademark, copyright or other notice from copies of the content.

However, you may download and print material from exclusively for your personal, noncommercial use.




up arrow