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CLL Overview

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Index of Articles

Updated: August 9, 2007

Current Publications

Experts Summaries Provide Reference Points for Clinicians

Citations of Useful Overviews

directions Here are some references to expert articles that should be useful to you and to your CLL doctor. They are recent scholarly articles that summarize the state of our understanding of CLL and recommend approaches to deal with it. If you would like to read any or all of these articles but have trouble locating or gaining access to them, please do write to us and we will be happy to help you.

The articles are all authored by top experts from Mayo Clinic, Ohio State and M. D. Anderson — and available as PDFs.

  • Diagnosis and Treatment of CLL

    Mayo Clinic Proceedings, August 2006
    Symposium on Oncology Practice: Hematological Malignancies
    Chronic Lymphocytic Leukemia: Diagnosis and Treatment
    Karen W. L. Yee, MD, and Susan M. O’Brien, MD

  • Initial Management of Newly Diagnosed, Early-Stage CLL

    Annals of Internal Medicine, September 2006
    Narrative Review
    Initial Management of Newly Diagnosed, Early-Stage Chronic Lymphocytic Leukemia
    Tait D. Shanafelt, MD; John C. Byrd, MD; Timothy G. Call, MD; Clive S. Zent, MD;
    and Neil E. Kay, MD

  • Prognostic Factors in Risk Stratification at Diagnosis and Time of Treatment.

    Current Opinion in Hematology 2006, 13:266–272
    Use of prognostic factors in risk stratification at diagnosis and time of treatment
    of patients with chronic lymphocytic leukemia

    Aruna Gowda and John C. Byrd

 

Risk-adapted Strategies

Experts Summarize the State of CLL Therapy

Where Are We?

Binoculars Drawing from a group of top-rated experts, Dr. Marco Montillo in Milan has produced an overview of where we are in understanding and treating CLL. Patients and their oncologists should pay close attention to the historical evidence and conclusions presented by this group. Read about it in Risk-adapted Strategies.

 

Staging is Superseded

The New Think on CLL Is Finally Here

The Dawn of a New Era

staging superceded An important new review article has been published in the New England Journal of Medicine. The Rai/Binet staging systems have been important in triggering therapy decisions. In this article the authors, who include Dr. Kanti Rai himself, bluntly state that the staging system with its emphasis on watch & wait should be replaced by better methods using modern prognostic indicators. We cover this important article as well as several other related works in The Dawn of a New Era.

 

Physicians' Corner

Progress in Finding a Cure

Are We There Yet?

Is FCR a Cure Professor Terry Hamblin needs no introduction to CLL patients. His seminal work on the prognostic value of the IgVH gene mutation status has become a cornerstone in the risk stratification of CLL patients. In his article, Are We There Yet?, Dr. Hamblin discusses criteria for initiating treatment as well as what treatment can and cannot do for the patient. He goes on to review the current status of combination chemo-immunotherapy clinical trials. Read this article for a candid assessment of where we are in the campaign to cure CLL.

 

 

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