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Alert Number 12

LMB-2 in Phase - II Trial Sponsored by NCI

Date: April 13, 2004

Novel Application of a New Anti-CD25 immunotoxin Offers Prospects of Highly Targeted and Effective Therapy.

We report on the recently announced clinical trial of a new immunotoxin, LMB-2, which shows early promise in attacking CLL cells. The technology has great potential if it is used in combination with immunomodulators such as bacterial-DNA derived CpG-ODN to up-regulate CD25, improving targeting of B-CLL cells. We discuss the background, results from early trials and the potential for effective treatment with low toxicity using this agent.

Here is the link to this just-published article:LMB-2.

Be well,

Chaya
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